Over Virussen (EBV, CMV, HSV, HHV6, HHV8, Coxsackie)

Nu beschikbaar: de vernieuwde HSV 1/2 EliSpot

Herpes Simplex virale (HSV) 1/2 infecties zijn gerelateerd aan CVS, Alzheimer en immuun-suppresie bij de Borrelia burgdorferi bacterie.
The new HSV 1/2-EliSpot together with the HSV 1/2-IgG/IgA/IgM-antibodies complement each other in the diagnosis of HSV 1/2-infections.

Over Epstein-Barr virus (EBV)

Epstein Barr Virus (obligate intracellular), double stranded DNA virus, one of the Herpes viruses, responsible for “Mononucleosis”.

Onze Testen EBV

EliSpot

EBV-EliSpot:
EBV lytisch antigen + EBV latente antigen
(2x ACD/CPDA tube)

IFT, ELISA, Immunoblot

EBV VCA-IgM (viraal capside antigen), -IgG VCA,
anti-EBNA (Epstein-Barr nucleair antigen) -antistoffen
(1x Serum/SST tube)

Virus:

Human Herpes Virus 4 (HHV-4) (intracellulaire)

Vector / transmissie:

direct contact met speeksel (50 % van alle vijfjarige kinderen en 90-95 % van de volwassenen in de Verenigde Staten zijn seropositief)

Symptomen (4-8 weken incubatietijd):

Klierkoorts (ziekte van Pfeiffer), malaise, anorexia, koude rillingen, koorts, cervicale lymfadenopathie, keelontsteking, splenomegalie, hepatitis, perifere atypische lymfocytose

Associaties:

Chronisch Vermoeiheid Syndroom (CVS), auto-immuunziekten (dermatomyositis, systemische lupus erythoematosus, reumatoïde artritis, syndroom van Sjögren's), Multiple Scleroris, kanker (Hodgkin lymphoma, Burkitt's lymphoma, nasofaryngeale carcinoom), aandoeningen geassocieerd met HIV (harige leukoplakie, centraal zenuwstelsel lyhmphomas)

Risicofactoren:

Immuunsysteem (kinderen, ouderen), jong volwassenen

Over Cytomegalovirus (CMV)

Virus: Cytomegalovirus (obligate intracellular), double-stranded DNA virus, one of the Herpes viruses.

Onze Testen CMV

EliSpot

CMV Elispot
(2x ACD/CPDA tube)

IFT, ELISA, Immunoblot

CMV-IgM- en IgG-antilichamen
(1x Serum/SST tube)

Virus:

Human Herpes Virus 5 (HHV-5) (intracellulaire)

Vector / transmissie:

speeksel, aerogeen, moedermelk, sperma, bloedtransfusie, uitstrijkje (cervicitis), weefsel transplantaties, aangeboren (60-90 % van de Amerikaanse volwassenen zijn seropositief)

Symptomen:

retinitis, oesofagitis, hepatitis, ileocolitis, aangeboren afwijkingen en neurologische afwijkingen

Associaties:

Chronisch Vermoeidheids Sydroom (CVS), sclerodermie, de ziekte van Menière, lichen planus, longfibrose, afteuze stomatitis

Risicofactoren:

immuunsysteemsuppresie (ouderen)

Over Herpes simplex Virus (HSV)

Herpes Simplex Virus (herpèsvirus humain HHV 1/2) (toujours intracellulaire), virus à ADN bicaténaire, un des virus de l'herpès.

Onze Testen HSV 1/2

EliSpot

HSV 1/2 EliSpot
(2x ACD/CPDA tube)

IFT, ELISA, Immunoblot

Herpes simplex 1 en Herpes simplex 2-IgG-/IgA-/-IgM-antilichamen
(1x Serum/SST tube)

Virus:

Herpes simplex virus 1 = Human herpesvirus 1 (HHV-1), Herpes simplex virus 2 = Human herpesvirus 2 (HHV-2) (intracellulair)

Vector / transmissie:

HSV-1 door een geïnfecteerde huid (luchtwegen, ogen of mond), HSV-2 door seksueel contact of tijdens de bevalling van zuigelingen

Symptomen:

vochthoudende blaasjes in de huid of mucosa van de mond, lippen, of de geslachtsdelen

Associaties:

Alzheimer ziekte (HSV-1), encefalitis (afasie)

Risicofactoren:

immuunsysteemsuppresie (kinderen, ouderen)

Varicella zoster virus (VZV)

Onze Testen VZV

EliSpot

VZV EliSpot
(2x ACD/CPDA tube)

IFT, ELISA, Immunoblot

VZV IgG-/IgA-/IgM-antilichamen
(1x Serum/SST tube)

Over Coxsackievirus

Coxsackievirus (obligate intracellular), belongs to Picornaviridae/enterovirus family, is a single-stranded RNA virus divided into group A and group B.

Onze Testen Coxsackievirus

IFT, ELISA, Immunoblot

Coxsackievirus-IgA- en IgG-antilichamen
(1x Serum/SST tube)

Virus:

Coxsackievirus A en B (Enterovirus)

Vector / transmissie:

fecaal-orale

Symptomen:

Coxsackievirus A:
huiduitslag, acute febriele respiratoire aandoeningen (herpangina), acute verlamming, conjunctivitis, myositis, carditis, pancreatitis
Coxsackievirus B:
huiduitslag, acute febriele respiratoire aandoeningen, aseptische meningitis, chorioretinitis, carditis, epidemische pleurodynia, fulminante hepatitis, hand-mond-en-klauwzeer, herpangina, meningitis, myocarditis, pericarditis, pleuritis

Associaties:

Coxsackievirus A:
pericarditis leidend tot hartfalen, conjunctivitis, luchtwegaandoeningen
Coxsackievirus B:
pericarditis leidend tot hartfalen, pleurodynie voor één week (acute thoracale of buikpijn met koorts en hoofdpijn, spierpijn, gewrichtspijn), virale meningits, insuline-afhankelijke diabetes (IDDM)

Risicofactoren:

immuunsysteemsuppresie

Over HHV6

Human Herpes Virus 6 (obligate intracellular), double-stranded DNA virus, one of the Herpes viruses.

Onze Testen HHV6

IFT, ELISA, Immunoblot

HHV 6-IgG-/IgM-antilichamen
(1x Serum/SST tube)

PCR

HHV-6 DNA-PCR
(2x EDTA tube)

Virus:

Human Herpes Virus 6 (HHV-6)

Vector / transmissie:

Speeksel (prevalentie van HHV-6 tussen de 3 en 90% in het speeksel)

Symptomen:

Exantheem subitum / "Roseola" (hoge koorts, gevolgd door een uitslag)

Verenigingen:

Chronische vermoeidheid Syndroom(CVS), multiple sclerose, Hashimoto's thyreoïditis, kanker (Kaposi's sarcoma), temporaalkwab epilepsie, optische neuritis, leverfalen

Risicofactoren:

immuunsysteemsuppresie

Onze Testen HHV7

Human herpesvirus 7

Onze Testen HHV7

IFT, ELISA, Immunoblot

HHV 7 IgG-antilichamen
(1x Serum/SST tube)

Over HHV8

Onze Testen HHV8

IFT, ELISA, Immunoblot

HHV-8-IgG-antilichamen
(1x Serum/SST tube)

PCR

HHV-8 DNA-PCR
(2x EDTA tube)

Virus:

Human Herpes Virus 8 (HHV-8)

Vector / transmissie:

Speeksel

Symptomen:

koorts, maculopapulaire uitslag

Associaties:

kanker (Kaposi's sarcoma)

Risicofactoren:

immuunsysteemsuppresie

Frühsommer-Meningoenzephalitis (FSME)

The tick-borne encephalitis (TBE) is a systemic infection caused by human-pathogenic TBE-virus. The TBE-virus gets with the tick bite directly through the salivary gland of the tick into the skin of its' victim.

Subsequently from there to the nearby lymph nodes and from there in other organs like e.g. connective tissue, musculosceletal, myocardium, also in monocytes and phagocytes, where the virus multiplies extremely. In the second viraemic stage the TBE-virus gets into the central nervous system and can reach the brain. With a direct or indirect proof of the TBE-virus, as far as it points to an infection, in Germany exists reporting obligation at the health authorities.

Onze Testen FSME

IFT, ELISA, Immunoblot

FSME IgG-/IgM-antilichamen
(1x Serum/SST tube)

Tick Test

Frühsommer-Meningoenzephalitis (FSME)-DNA-PCR
(van de teek)

Enterovirus

Enteroviruses belong to the family of picorna viruses. They consist of 23 subspecies of Coxsackie-A-viruses, 6 Coxsackie-B-viruses and 31 Echo- and and other Enteroviruses.

Humans are the only virus reservoir. The Enteroviruses are causing feverish diseases of the respiratory organs and the gastro intestinal tract but also encephalitis, lymphocytic meningitis, fatique, myalgia, pericarditis and myocarditis, hepatitis, IDDM (insulin-dependent diabetes mellitus) as well as Herpangina, Hand-Foot-and-Mouth disease (HFM).

Onze Testen Enterovirus

IFT, ELISA, Immunoblot

Enterovirus IgG-/IgM-antilichamen
(1x Serum/SST tube)

Parvovirus B19

Parvovirus B19 is characterized by a high stability towards environmental factors and detergents. The virus attacks a receptor on the erythrocytes, the globoside blood group-p-antigen.

The Parvovirus B19 infection (Fifth Disease, Erythrema infectiosum) can be found all over the world, especially in spring, local epidemics, preferred in kindergarten, schools, families and in hospital areas. The infection can induce for adults acral erythrema and arthritis. Parvovirus multiplies in erythroblasts and trigger in this way a temporary anemia. The infection may lead for immunocompromised people to complications and also death.

Onze Testen Parvovirus

IFT, ELISA, Immunoblot

Parvovirus B19 IgG-/IgM-antilichamen
(1x Serum/SST tube)

Echovirus

ECHO-virus causes in the beginning mainly asymptomatic infections, where neutralizing antibodies are formed.

The virus reproduces itself in the intestinal tract and may get subsequently through the lymphatic system into the blood circulation and may lead to cyclic infections with viremia as well as to a spread to the target organs. ECHO-virus shows a wide spectrum of diseases and may attack the following organs: digestive tract, meninges, CNS, myocardium, pericardium, striated muscle, respiratory tract and skin. Most ECHO-viruses are associated with infections of the CNS, from which the aseptic meningitis should be mentioned.

Onze Testen Echovirus

IFT, ELISA, Immunoblot

Echovirus IgG-/IgM-antilichamen
(1x Serum/SST tube)