Herpes Simplex Virus (HSV) 1/2 infections are associated with CFS, Alzheimer´s disease and immune-suppression by bacteria like Borrelia burgdorferi.
The new HSV 1/2-EliSpot together with the HSV 1/2-IgG/IgA/IgM-antibodies complement each other in the diagnosis of HSV 1/2-infections.
Human Herpes Virus 4 (HHV-4) (obligate intracellular)
Direct contact with saliva: “Kissing disease”, saliva, drinking from the same glass, toothbrush, blood, sex, blood-transfusion, organ transplantation.
50 % of all five-year-old children and 90-95 % of the adults in the USA are seropositive.
Infectious Mononucleosis (glandular fever), malaise, anorexia, chills, fever, cervical lymphadenopathy, pharyngitis, splenomegaly, hepatitis, peripheral atypical lymphocytosis
Chronic Fatique Sydrome (CFS), autoimmune diseases (dermatomyositis, systemic lupus erythoematosus, rheumatoid arthritis, Sjögren´s syndrome), Multiple Scleroris, cancer (Hodgkin´s lymphoma, Burkitt´s lymphoma, nasopharyngeal carcinoma), conditions associated with HIV (hairy leukoplakia, central nervous system lyhmphomas)
Immune suppression (children, elder people), young adults.
Human Herpes Virus 5 (HHV-5) (intracellular)
Airborne transmission, smear (cervicitis), tissue transplants, congenital (60-90% of US adults are seropositive), body fluids (urine, saliva, breast milk, sexual transmission/semen), organ transplantation, blood transfusion.
Fatigue, fever, flu-like symptoms, lymphadenitis (swollen cervical lymph nodes), sore throat, splenomegaly, retinitis, esophagitis, hepatitis, ileocolitis, congenital abnormalities and neurological deficits.
Chronic Fatique Sydrome (CFS), scleroderma, Meniere´s disease, lichen planus, pulmonary fibrosis, aphtous stomatitis
immune suppression (elder people)
Herpes simplex Virus 1 = Human Herpes Virus 1 (HHV-1)
Herpes simplex Virus 2 = Human Herpes Virus 2 (HHV-2) (intracellular).
HSV 1 by an infected skin-area (respiratory tract, eyes or mouth), HSV 2 by sexual contact or during childbirth for infants
Watery blisters on the skin or mucous membranes of the mouth, lips, genitals, anus, flu-like symptoms (fever, muscle aches, swollen lymph nodes, problems urinating, herpes keratitis (pain, light sensitivity, discharge: sexual tract/mouth area).
Multiple Sclerosis (neurovirulent), Alzheimer´s disease (HSV1), loss of vision, encephalitis (aphasia), latent infection; reactivation by organ transplantation or HIV: encephalitis, pneumonitis, bone marrow suppression.
immune suppression (children, elder people)
Coxsackievirus A and B (Enterovirus).
Coxsackievirus (obligate intracellular), belongs to Picornaviridae/ enterovirus family, is a single-stranded RNA virus divided into group A and group B.
Fecal-oral contamination, droplets, body fluids, utensils, toys, diaper-changing table.
Herpangina, AHC (acute hemorrhagic conjunctivitis, HFM (hand-foot-and-mouth disease);
Myocarditis, pericarditis, pleurodynia, hepatitis;
Coxsackievirus A and B:
Fever, rashes, sore throat, diahorrea, cough, fatigue, conjunctivitis, loss of appetite, headache, night sweats, aseptic meningitis.
pericarditis progressing to heart failure, conjunctivitis, respiratory disease
pericarditis progressing to heart failure, pleurodynia for one week (acute chest or abdominal pain with fever and headache, myalgia, joint pain), viral meningits, Insulin-dependent diabetes (IDDM)
Human Herpes Virus 6 (HHV-6)
Saliva: shedding of viral particles into saliva (prevalance of HHV-6 between 3 and 90% in saliva), latency in salivary glands, haematopoetic (blood-building) system.
Exanthema subitum (Roseola infantum, sixth disease) with high temperature followed by a rash.
Co-factor in Chronic fatique syndrome (CFS), Multiple Sclerosis (neurovirulent), Hashimoto´s thyroiditis, cancer (Kaposi´s sarkoma), temporal lobe epilepsy, optic neuritis, hepatic dysfunction/failure, fibromyalgia, AIDS, cancer temporal lobe epilepsy, reactivation by organ transplantation: encephalitis, pneumonitis, bone marrow suppression.
Human Herpes Virus 8 (HHV-8)
shedding of viral particles into saliva
fever, maculopapular rash
cancer (Kaposi´s sarkoma)