Virus: Cytomegalovirus (obligate intracellular), double-stranded DNA virus, one of the Herpes viruses.

Herpes Simplex Virus (herpèsvirus humain HHV 1/2) (toujours intracellulaire), virus à ADN bicaténaire, un des virus de l'herpès.

Coxsackievirus (obligate intracellular), belongs to Picornaviridae/enterovirus family, is a single-stranded RNA virus divided into group A and group B.

Human Herpes Virus 6 (obligate intracellular), double-stranded DNA virus, one of the Herpes viruses.

Subsequently from there to the nearby lymph nodes and from there in other organs like e.g. connective tissue, musculosceletal, myocardium, also in monocytes and phagocytes, where the virus multiplies extremely. In the second viraemic stage the TBE-virus gets into the central nervous system and can reach the brain. With a direct or indirect proof of the TBE-virus, as far as it points to an infection, in Germany exists reporting obligation at the health authorities.

Humans are the only virus reservoir. The Enteroviruses are causing feverish diseases of the respiratory organs and the gastro intestinal tract but also encephalitis, lymphocytic meningitis, fatique, myalgia, pericarditis and myocarditis, hepatitis, IDDM (insulin-dependent diabetes mellitus) as well as Herpangina, Hand-Foot-and-Mouth disease (HFM).

The Parvovirus B19 infection (Fifth Disease, Erythrema infectiosum) can be found all over the world, especially in spring, local epidemics, preferred in kindergarten, schools, families and in hospital areas. The infection can induce for adults acral erythrema and arthritis. Parvovirus multiplies in erythroblasts and trigger in this way a temporary anemia. The infection may lead for immunocompromised people to complications and also death.

The virus reproduces itself in the intestinal tract and may get subsequently through the lymphatic system into the blood circulation and may lead to cyclic infections with viremia as well as to a spread to the target organs. ECHO-virus shows a wide spectrum of diseases and may attack the following organs: digestive tract, meninges, CNS, myocardium, pericardium, striated muscle, respiratory tract and skin. Most ECHO-viruses are associated with infections of the CNS, from which the aseptic meningitis should be mentioned.