Epstein Barr Virus (obligate intracellular), double stranded DNA virus, one of the Herpes viruses, responsible for “Mononucleosis”.
EBV-EliSpot:
EBV lytic antigen + EBV latent antigen
(2x ACD/CPDA tube)
EBV-IgM VCA (viral capsid antigen), -IgG VCA,
anti-EBNA (Epstein-Barr nuclear antigen)-antibodies
(1x Serum/SST tube)
Human Herpes Virus 4 (HHV-4) (obligate intracellular)
Direct contact with saliva: “Kissing disease”, saliva, drinking from the same glass, toothbrush, blood, sex, blood-transfusion, organ transplantation.
50 % of all five-year-old children and 90-95 % of the adults in the USA are seropositive.
Infectious Mononucleosis (glandular fever), malaise, anorexia, chills, fever, cervical lymphadenopathy, pharyngitis, splenomegaly, hepatitis, peripheral atypical lymphocytosis
Chronic Fatique Sydrome (CFS), autoimmune diseases (dermatomyositis, systemic lupus erythoematosus, rheumatoid arthritis, Sjögren´s syndrome), Multiple Scleroris, cancer (Hodgkin´s lymphoma, Burkitt´s lymphoma, nasopharyngeal carcinoma), conditions associated with HIV (hairy leukoplakia, central nervous system lyhmphomas)
Immune suppression (children, elder people), young adults.