About Epstein-Barr-Virus (EBV)

Epstein Barr Virus (obligate intracellular), double stranded DNA virus, one of the Herpes viruses, responsible for “Mononucleosis”.

Available Tests for EBV


EBV lytic antigen + EBV latent antigen
(2x ACD/CPDA tube)

IFA, ELISA, Immunoblot

EBV-IgM VCA (viral capsid antigen), -IgG VCA,
anti-EBNA (Epstein-Barr nuclear antigen)-antibodies
(1x Serum/SST tube)


Human Herpes Virus 4 (HHV-4) (obligate intracellular)

Vector / Transmission:

Direct contact with saliva: “Kissing disease”, saliva, drinking from the same glass, toothbrush, blood, sex, blood-transfusion, organ transplantation.
50 % of all five-year-old children and 90-95 % of the adults in the USA are seropositive.

Symptoms (4-8 weeks incubation period):

Infectious Mononucleosis (glandular fever), malaise, anorexia, chills, fever, cervical lymphadenopathy, pharyngitis, splenomegaly, hepatitis, peripheral atypical lymphocytosis


Chronic Fatique Sydrome (CFS), autoimmune diseases (dermatomyositis, systemic lupus erythoematosus, rheumatoid arthritis, Sjögren´s syndrome), Multiple Scleroris, cancer (Hodgkin´s lymphoma, Burkitt´s lymphoma, nasopharyngeal carcinoma), conditions associated with HIV (hairy leukoplakia, central nervous system lyhmphomas)

Risk factors:

Immune suppression (children, elder people), young adults.