About Viruses (EBV, CMV, HSV, HHV6, HHV8, Coxsackie)

Now offering the new HSV 1/2 EliSpot

Herpes Simplex Virus (HSV) 1/2 infections are associated with CFS, Alzheimer´s disease and immune-suppression by bacteria like Borrelia burgdorferi.
The new HSV 1/2-EliSpot together with the HSV 1/2-IgG/IgA/IgM-antibodies complement each other in the diagnosis of HSV 1/2-infections.

(if not yet included in the Test Order Form please write "HSV 1/2 EliSpot" into the empty box at the bottom of the Order-Box)

About Epstein-Barr virus (EBV)

Available Tests for EBV

Antibodies

EBV-IgM VCA (viral capsid antigen), -IgG VCA,
anti-EBNA (Epstein-Barr nuclear antigen)-antibodies
(Serum tube)

EliSpot

EBV-EliSpot:
EBV lytic antigen + EBV latent antigen
(CPDA tube)

Virus:

Human Herpes Virus 4 (HHV-4)(intracellular)

Vector / Transmission:

direct contact with saliva (50% of all five-year-old children and 90-95% of adults in USA are seropositive)

Symptoms (4-8 weeks incubation period):

Infectious Mononucleosis (glandular fever), malaise, anorexia, chills, fever, cervical lymphadenopathy, pharyngitis, splenomegaly, hepatitis, peripheral atypical lymphocytosis

Associations:

Chronic Fatique Sydrome (CFS), autoimmune diseases (dermatomyositis, systemic lupus erythoematosus, rheumatoid arthritis, Sjögren´s syndrome), Multiple Scleroris, cancer (Hodgkin´s lymphoma, Burkitt´s lymphoma, nasopharyngeal carcinoma), conditions associated with HIV (hairy leukoplakia, central nervous system lyhmphomas)

Risk factors:

immune suppression (children, elder people), young adults

About Cytomegalovirus (CMV)

Available Tests for CMV

Antibodies

CMV-IgM- and -IgG-antibodies
(Serum tube)

Virus:

Human Herpes Virus 5 (HHV-5) (intracellular)

Vector / Transmission:

saliva, airborne, breast milk, semen, blood transfusion, smear (cervicitis), tissue transplants, congenital (60-90% of US adults are seropositive)

Symptoms:

retinitis, esophagitis, hepatitis, ileocolitis, congenital abnormalities and neurological deficits

Associations:

Chronic Fatique Sydrome (CFS), scleroderma, Meniere´s disease, lichen planus, pulmonary fibrosis, aphtous stomatitis

Risk factors:

immune suppression (elder people)

About Herpes simplex Virus (HSV)

Available Tests for HSV

Antibodies

Herpes simplex 1 and Herpes simplex 2 antibodies
(Serum tube)

EliSpot

HSV 1/2 EliSpot
(CPDA tube)

Virus:

Herpes simplex Virus 1 = Human Herpes Virus 1 (HHV-4), Herpes simplex Virus 2 = Human Herpes Virus 2 (HHV-2) (intracellular)

Vector / Transmission:

HSV 1 by an infected skin-area (respiratory tract, eyes or mouth), HSV 2 by sexual contact or during childbirth for infants

Symptoms:

watery blisters in the skin or mucuos membranes of the mouth, lips, or genitals

Associations:

Alzheimer´s disease (HSV1), encephalitis (aphasia)

Risk factors:

immune suppression (children, elder people)

About HHV6

Available Tests for HHV6

Antibodies

HHV-6-antibodies
(Serum tube)

PCR

HHV-6 DNA-PCR
(EDTA tube)

Virus:

Human Herpes Virus 6 (HHV-6)

Vector / Transmission:

shedding of viral particles into saliva (prevalance of HHV-6 between 3 and 90% in saliva)

Symptoms:

Exanthema subitum / ”Roseola” (high fever followed by a rash)

Associations:

Chronic fatique syndrome (CFS), Multiple Sclerosis, Hashimoto´s thyroiditis, cancer (Kaposi´s sarkoma), temporal lobe epilepsy, optic neuritis, hepatic failure

Risk factors:

immune suppression

About HHV8

Available Tests for HHV8

Antibodies

HHV-8-antibodies
(Serum tube)

PCR

HHV-8 DNA-PCR
(EDTA tube)

Virus:

Human Herpes Virus 8 (HHV-8)

Vector / Transmission:

shedding of viral particles into saliva

Symptoms:

fever, maculopapular rash

Associations:

cancer (Kaposi´s sarkoma)

Risk factors:

immune suppression

About Coxsackie

Available Tests for Coxsackie

Antibodies

Coxsackie Virus-IgA- and IgG-antibodies
(Serum tube)

Virus:

Coxsackie-virus A and B (Enterovirus)

Vector / Transmission:

fecal-oral

Symptoms:

Coxsackie A:
rashes, acute febrile respiratory disease (herpangina), acute flaccid paralysis, conjunctivitis, carditis, myositis, carditis, pancreatitis
Coxsackie B:
rashes, acute febrile respiratory disease, aseptic meningitis, chorioretinitis, carditis, epidemic pleurodynia, fulminant hepatitis, hand-foot-and-mouth disease, herpangina, meningitis, myocarditis, pericarditis, pleurisy

Associations:

Coxsackie A:
pericarditis progressing to heart failure, conjunctivitis, respiratory disease
Coxsackie B:
pericarditis progressing to heart failure, pleurodynia for one week (acute chest or abdominal pain with fever and headache, myalgia, joint pain), viral meningits, Insulin-dependent diabetes (IDDM)

Risk factors:

immune suppression